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Sofosbuvir mechanism

Sofosbuvir treatment response People who experience a rapid drop in HCV viral load soon after starting treatment are more likely to be cured. People with sustained sofosbuvir mechanism virological response, these factors may be overcome by longer treatment or by adding another direct-acting antiviral drug.

Sofosbuvir (brand name Sovaldi )) is a new medication used to treat hepatitis C. C. For some people, it was approved in Europe in January 2014 for treatment of adults with all genotypes of chronic hepatitis.

Sofosbuvir can be used sofosbuvir mechanism by people being treated for hepatitis C for the first time (known as 'treatment-naive and for retreatment of people who were not cured with previous interferon-based therapy (known as 'treatment-experienced.)

Several factors predict sofosbuvir mechanism how well someone will respond, extent of liver damage and previous treatment history. Sofosbuvir works better for some people than for others. How effective is sofosbuvir? Including HCV genotype,

Фармакологическое действие

The FUSION trial looked at previously treated people sofosbuvir mechanism with genotypes 2 or 3 (mostly prior relapsers)) who took sofosbuvir plus ribavirin for 12 or 16 weeks. For genotype 3 patients with cirrhosis, the cure rate fell to just 34.however,

Фармакокинетика

Information about specific drug interactions is available online at www. Sofosbuvir is available by prescription in European Union countries to treat all genotypes of hepatitis sofosbuvir mechanism C. Hep-druginteractions. John's wort. Org. How can I get sofosbuvir?

Показания

Sofosbuvir is generally well tolerated with no known specific side-effects of its own. The most common side-effects seen in people taking sofosbuvir with ribavirin or pegylated interferon/ribavirin are fatigue, headache, nausea and insomnia. Interferon and ribavirin can cause other side-effects including muscle and joint aches.

It is a nucleotide analogue HCV polymerase inhibitor, meaning it blocks the polymerase enzyme which the virus must use to reproduce. Sofosbuvir should be combined with other medications, which may include pegylated interferon (which stimulates the body's own immune response ribavirin or other direct-acting antivirals.

Противопоказания

In fact, overall, the FISSION study looked at previously untreated people with HCV genotypes 2 or 3. There are few data at all sofosbuvir mechanism for genotypes 5 and 6. Sofosbuvir has not been well studied in treatment-experienced people with genotypes 1, 4, 5 and 6.use of sofosbuvir in combinations Sofosbuvir is also available in the combination pills Harvoni (in combination with ledipasvir)) and Epclusa sofosbuvir mechanism (in combination with velpatasvir)). See the factsheets on Harvoni and Epclusa for more information about these combinations.

Data софосбувир и даклатасвир после лечения алкоголь prod by lil smooky on safety and efficacy in decompensated cirrhosis have not yet been published. People with chronic hepatitis C who are awaiting or have received a liver transplant tolerate sofosbuvir better than older medications. It works better for people with less advanced liver damage. However,

Those who cannot use interferon can take sofosbuvir plus ribavirin alone for 24 weeks. People with HCV genotype 2 should take sofosbuvir with ribavirin alone for 12 weeks. Genotype 3 is harder to treat, so these patients should either extend sofosbuvir plus ribavirin to 24.

Response rates were high even for previous non-responders and people with cirrhosis using the longer duration. The PHOTON -1 study tested sofosbuvir plus ribavirin for people with HIV and HCV co-infection. The cure rate was about 75 for people with HCV genotype 2 or 3.

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Беременность и лактация

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Побочные действия

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Продолжение Sofosbuvir mechanism

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